Engineering Science of Biomembrane-Mediated Crystallization

Complexation-mediated crystallization

Crown ether complexation solubilizes organic and inorganic salts in nonpolar media. Induction of crystallization from such solutions can result in crystallization of the free salt rather than the complex. This affords the opportunity to examine solvent effects on the crystallization of salts and other polar materials, leading to the modification of crystal shape and lattice. This approach, whic...

Entropy and surface engineering in protein crystallization.

Protein crystallization remains a key limiting step in the characterization of the atomic structures of proteins and their complexes by X-ray diffraction methods. Current data indicate that standard screening procedures applied to soluble well folded prokaryotic proteins yield X-ray diffraction crystals with an approximately 20% success rate and for eukaryotic proteins this figure may be signif...

Fab-mediated Crystallization of a Potassium Channel

Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

Many biomineralization systems start from transient amorphous precursor phases, but the exact crystallization pathways and mechanisms remain largely unknown. The study of a well-defined biomimetic crystallization system is key for elucidating the possible mechanisms of biomineralization and monitoring the detailed crystallization pathways. In this review, we focus on amorphous phase mediated cr...

Computer Science : Craft , Science or Engineering ?

There has been a lot of philosophical and pragmatic debate on whether Computer Science is a craft, science or an engineering discipline. This article examines both Paul Graham’s claim that hackers and painters have a lot in common and Dr. Tolbert’s claim that Computer Science is a craft on its way to becoming an engineering discipline. We conclude that both claims have truth in them and argue t...